2021年氢医学生物学研究论文汇编

发布时间：2022-03-08本文来源：氢思语

2021年氢气医学生物学论文超过200篇，由于数据库的延迟，可能会有一些出入，中文文献显然有更多没有检索到。这一年的文献大概有如下特点，1材料学特别是镁生物材料方面的文献比较多，2植物学研究文章比较多，3临床研究相对比较多，4综述性文献比较多，5多篇新冠肺炎方面的文章。本汇编主要根据谷歌学术检索2007年文献被引用的情况。

过去的1年发表200篇，2022年估计至少200篇，氢气医学的发展速度可见一斑。

许多人氢气医学业内人士表示，在健康产业领域，产品非常多，但如氢气医学这样有众多学术支持的产品非常少，氢气医学是不可多得，百年一遇的理想健康概念。

氢思语认为，所以氢气医学会有这样多学者关注和深入研究，有两个根本原因，一是氢气真正是理想的健康和医学工具，能给人健康和疾病防治带来实实在在的效果，二是氢气医学是新兴领域，还存在许多问题需要解决。有应用价值是开展研究的落脚点，说明值得研究。存在科学问题是开展研究的驱动力，这才有研究兴趣。

Xu C, Wang S, Wang H, et al. Magnesium-based micromotors as Hydrogen generators for precise rheumatoid arthritis therapy[J]. Nano Letters, 2021, 21(5): 1982-1991.
Wu Y, Su L, Yuan M, et al. In Vivo X‐ray Triggered Catalysis of H2 Generation for Cancer Synergistic Gas Radiotherapy[J]. Angewandte Chemie International Edition, 2021, 60(23): 12868-12875.
Chen J, Lin S, Zhao D, et al. Palladium Nanocrystals‐Engineered Metal–Organic Frameworks for Enhanced Tumor Inhibition by Synergistic Hydrogen/Photodynamic Therapy[J]. Advanced Functional Materials, 2021, 31(4): 2006853.
Rahman M, Bajgai J, Fadriquela A, et al. Redox effects of molecular Hydrogen and its therapeutic efficacy in the treatment of neurodegenerative diseases[J]. Processes, 2021, 9(2): 308.
Wang S, Liu K, Zhou Q, et al. Hydrogen‐Powered Microswimmers for Precise and Active Hydrogen Therapy Towards Acute Ischemic Stroke[J]. Advanced Functional Materials, 2021, 31(19): 2009475.
Yun Z, Gao H, Chen X, Chen Z, Zhang Z, Li T, Qu H, Jiang Y. Effects of Hydrogen water treatment on antioxidant system of litchi fruit during the pericarp browning. Food Chem. 2021 Jan 30;336:127618
Jin Z, Sun Y, Yang T, et al. Nanocapsule-mediated sustained H2 release in the gut ameliorates metabolic dysfunction-associated fatty liver disease[J]. Biomaterials, 2021, 276: 121030.
Alwazeer D, Liu F F C, Wu X Y, et al. Combating oxidative stress and inflammation in COVID-19 by molecular Hydrogen therapy: Mechanisms and perspectives[J]. Oxidative medicine and cellular longevity, 2021, 2021.
Su J, Yang X, Shao Y, et al. Molecular hydrogen–induced salinity tolerance requires melatonin signalling in Arabidopsis thaliana[J]. Plant, Cell & Environment, 2021, 44(2): 476-490.
Li Y, Xu J, Mi J, et al. Biodegradable magnesium combined with distraction osteogenesis synergistically stimulates bone tissue regeneration via CGRP-FAK-VEGF signaling axis[J]. Biomaterials, 2021, 275: 120984.
Maggio G, Squadrito G, Nicita A. Hydrogen and medical oxygen by renewable energy based electrolysis: A green and economically viable route[J]. Applied Energy, 2022, 306: 117993.
Li Y, Li L, Wang S, et al. Magnesium hydride acts as a convenient Hydrogen supply to prolong the vase life of cut roses by modulating nitric oxide synthesis[J]. Postharvest Biology and Technology, 2021, 177: 111526.
Li L, Lou W, Kong L, et al. Hydrogen commonly applicable from medicine to agriculture: From molecular mechanisms to the field[J]. Current Pharmaceutical Design, 2021, 27(5): 747-759.
Nie C, Ding X, Rong A, et al. Hydrogen gas inhalation alleviates myocardial ischemia-reperfusion injury by the inhibition of oxidative stress and NLRP3-mediated pyroptosis in rats[J]. Life Sciences, 2021, 272: 119248.
Hancock J T, Russell G. Downstream signalling from molecular hydrogen[J]. Plants, 2021, 10(2): 367.
Wang Y, Lv P, Kong L, et al. Nanomaterial-mediated sustainable Hydrogen supply induces lateral root formation via nitrate reductase-dependent nitric oxide[J]. Chemical Engineering Journal, 2021, 405: 126905.
Jiang K, Kuang Y, Feng L, et al. Molecular Hydrogen maintains the storage quality of Chinese chive through improving antioxidant capacity[J]. Plants, 2021, 10(6): 1095.
Liu S, Li J, Oshita S, et al. Formation of a Hydrogen radical in Hydrogen nanobubble water and its effect on copper toxicity in Chlorella[J]. ACS Sustainable Chemistry & Engineering, 2021, 9(33): 11100-11109.
Wang C, Wang W, Tan J, et al. Coordination-based molecular nanomaterials for biomedically relevant applications[J]. Coordination Chemistry Reviews, 2021, 438: 213752.
Liu Y, Li H, Xu J, et al. Biodegradable metal-derived magnesium and sodium enhances bone regeneration by angiogenesis aided osteogenesis and regulated biological apatite formation[J]. Chemical Engineering Journal, 2021, 410: 127616.
Zolotarenko A D, Zolotarenko A D, Veziroglu A, et al. The use of ultrapure molecular Hydrogen enriched with atomic Hydrogen in apparatuses of artificial lung ventilation in the fight against virus COVID-19[J]. International journal of Hydrogen energy, 2021.
Walia V, Kaushik D, Mittal V, et al. Delineation of Neuroprotective Effects and Possible Benefits of AntioxidantsTherapy for the Treatment of Alzheimer’s Diseases by Targeting Mitochondrial-Derived Reactive Oxygen Species: Bench to Bedside[J]. Molecular neurobiology, 2021: 1-24.
Li L, Yin Q, Zhang T, et al. Hydrogen nanobubble water delays petal senescence and prolongs the vase life of cut carnation (Dianthus caryophyllus L.) flowers[J]. Plants, 2021, 10(8): 1662.
Slezak J, Kura B, LeBaron T W, et al. Oxidative stress and pathways of molecular Hydrogen effects in medicine[J]. Current Pharmaceutical Design, 2021, 27(5): 610-625.
Li L, Zeng Y, Cheng X, et al. The Applications of Molecular Hydrogen in Horticulture[J]. Horticulturae, 2021, 7(11): 513.
Zan R, Wang H, Cai W, et al. Controlled release of Hydrogen by implantation of magnesium induces P53-mediated tumor cells apoptosis[J]. Bioactive materials, 2022, 9: 385-396.
Bai L, Yi W, Wang Y, et al. A PdMo bimetallene with precise wavelength adjustment and catalysis for synergistic photothermal ablation and Hydrogen therapy of cancer at different depths[J]. Journal of Materials Chemistry B, 2021, 9(32): 6441-6459.
Wu M, Xie X, Wang Z, et al. Hydrogen-rich water alleviates programmed cell death induced by GA in wheat aleurone layers by modulation of reactive oxygen species metabolism[J]. Plant Physiology and Biochemistry, 2021, 163: 317-326.
Chen W, Zhang H T, Qin S C. Neuroprotective effects of molecular hydrogen: A critical review[J]. Neuroscience Bulletin, 2021, 37(3): 389-404.
Zan R, Ji W, Qiao S, et al. Biodegradable magnesium implants: a potential scaffold for bone tumor patients[J]. Science China Materials, 2021, 64(4): 1007-1020.
Ohta S. Direct targets and subsequent pathways for molecular Hydrogen to exert multiple functions: Focusing on interventions in radical reactions[J]. Current Pharmaceutical Design, 2021, 27(5): 595-609.
Köktürk M, Yıldırım S, Eser G, et al. Hydrogen-rich water alleviates the nickel-induced toxic responses (inflammatory responses, oxidative stress, DNA damage) and ameliorates cocoon production in earthworm[J]. Biological Trace Element Research, 2021: 1-11.
Zhang Z, Sun X, Wang K, et al. Hydrogen-saturated saline mediated neuroprotection through autophagy via PI3K/AKT/mTOR pathway in early and medium stages of rotenone-induced Parkinson’s disease rats[J]. Brain Research Bulletin, 2021, 172: 1-13.
Fan L, Chen H, Liang J, et al. Controllable synthesis of Hydrogen bubbles via aeration method for efficient antioxidant process[J]. Applied Nanoscience, 2021, 11(3): 833-840.
Takewaki F, Nakajima H, Takewaki D, et al. Habitual dietary intake affects the altered pattern of gut microbiome by acarbose in patients with type 2 diabetes[J]. Nutrients, 2021, 13(6): 2107.
Mineo G, Moulaee K, Neri G, et al. H2 detection mechanism in chemoresistive sensor based on low-cost synthesized WO3 nanorods[J]. Sensors and Actuators B: Chemical, 2021, 348: 130704.
Chen H, Guo Y, Zhang Z, et al. Symbiotic Algae–Bacteria Dressing for Producing Hydrogen to Accelerate Diabetic Wound Healing[J]. Nano Letters, 2021.
Zulfiqar F, Russell G, Hancock J T. Molecular Hydrogen in agriculture[J]. Planta, 2021, 254(3): 1-14.
Zheng M, Yu H, Xue Y, et al. The protective effect of Hydrogen-rich water on rats with type 2 diabetes mellitus[J]. Molecular and Cellular Biochemistry, 2021, 476(8): 3089-3097.
Chen K D, Lin W C, Kuo H C. Chemical and biochemical aspects of molecular Hydrogen in treating Kawasaki Disease and COVID-19[J]. Chemical Research in Toxicology, 2021, 34(4): 952-958.
Li Q, Hu L, Li J, et al. Hydrogen attenuates endotoxin-induced lung injury by activating thioredoxin 1 and decreasing tissue factor expression[J]. Frontiers in Immunology, 2021, 12.
Liu F, Lou W, Wang J, et al. Glutathione produced by γ-glutamyl cysteine synthetase acts downstream of Hydrogen to positively influence lateral root branching[J]. Plant Physiology and Biochemistry, 2021, 167: 68-76.
Hou X, Qi N, Wang C, et al. Hydrogen-rich water promotes the formation of bulblets in Lilium davidii var. unicolor through regulating sucrose and starch metabolism[J]. Planta, 2021, 254(5): 1-16.
Hu H W, Chen Z G, Liu J G, et al. Role of Hydrogen in traumatic brain injury: a narrative review[J]. Medical Gas Research, 2021, 11(3): 114.
Saitoh Y, Yamaguchi Y, Okada Y. Protective effects of dissolved molecular Hydrogen against Hydrogen peroxide-, hydroperoxide-, and glyoxal-induced injuries to human skin keratinocytes[J]. Molecular and Cellular Biochemistry, 2021, 476(10): 3613-3622.
Zheng Z G, Sun W Z, Hu J Y, et al. Hydrogen/oxygen therapy for the treatment of an acute exacerbation of chronic obstructive pulmonary disease: results of a multicenter, randomized, double-blind, parallel-group controlled trial[J]. Respiratory research, 2021, 22(1): 1-12.
Xie K, Wang Y, Yin L, et al. Hydrogen gas alleviates sepsis-induced brain injury by improving mitochondrial biogenesis through the activation of PGC-α in mice[J]. Shock, 2021, 55(1): 100-109.
Peng H, Fan K, Zan R, et al. Degradable magnesium implants inhibit gallbladder cancer[J]. Acta biomaterialia, 2021, 128: 514-522.
Gong W, Jiang L, Zhu Y, et al. An Activity‐Based Ratiometric Fluorescent Probe for In Vivo Real‐Time Imaging of Hydrogen Molecules[J]. Angewandte Chemie International Edition, 2021.
Sano M, Tamura T. Hydrogen gas therapy: From preclinical studies to clinical trials[J]. Current Pharmaceutical Design, 2021, 27(5): 650-658.
Jafta N, Magagula S, Lebelo K, et al. The Production and Role of Hydrogen‐Rich Water in Medical Applications[J]. Applied Water Science Volume 1: Fundamentals and Applications, 2021: 273-298.
Zhu B, Cui H, Xu W. Hydrogen inhibits the proliferation and migration of gastric cancer cells by modulating lncRNA MALAT1/miR-124-3p/EZH2 axis[J]. Cancer Cell International, 2021, 21(1): 1-10.
Tanaka Y, Kiuchi M, Higashimura Y, et al. The effects of ingestion of hydrogen-dissolved alkaline electrolyzed water on stool consistency and gut microbiota: A double-blind randomized trial[J]. Medical Gas Research, 2021, 11(4): 138.
Jin D, Zhang J, Huang Y, et al. Recent advances in the development of metal–organic framework-based gas-releasing nanoplatforms for synergistic cancer therapy[J]. Dalton Transactions, 2021, 50(4): 1189-1196.
Li L, Wang J, Jiang K, et al. Preharvest application of Hydrogen nanobubble water enhances strawberry flavor and consumer preferences[J]. Food Chemistry, 2022, 377: 131953.
Lucas K, Rosch M, Langguth P. Molecular Hydrogen (H2) as a potential treatment for acute and chronic fatigue[J]. Archiv der Pharmazie, 2021, 354(4): 2000378.
Liu B, Zhao M, Xue J, et al. Hydrogen influences HDL-associated enzymes and reduces oxidized phospholipids levels in rats fed with a high-fat diet[J]. Life Sciences, 2021, 267: 118945.
Amukarimi S, Mozafari M. Biodegradable magnesium‐based biomaterials: An overview of challenges and opportunities[J]. MedComm, 2021, 2(2): 123-144.
Zhang C S, Han Q, Song Z W, et al. Hydrogen gas postconditioning attenuates early neuronal pyroptosis in a rat model of subarachnoid hemorrhage through the mitoK ATP signaling pathway[J]. Experimental and Therapeutic Medicine, 2021, 22(2): 1-10.
Ma L, Kong L, Gui R, et al. Application of Hydrogen-rich water modulates physio-biochemical functions and early growth of fragrant rice under Cd and Pb stress[J]. Environmental Science and Pollution Research, 2021, 28(41): 58558-58569.
Qin S. Role of Hydrogen in atherosclerotic disease: from bench to bedside[J]. Current Pharmaceutical Design, 2021, 27(5): 713-722.
Matsuura H, Matsumoto H, Okuzaki D, et al. Hydrogen gas therapy attenuates inflammatory pathway signaling in septic mice[J]. Journal of Surgical Research, 2021, 263: 63-70.
Saitoh Y, Kawasaki N, Eguchi N, et al. Combined treatment with dissolved Hydrogen molecule and platinum nanocolloid exerts carcinostatic/carcinocidal effects by increasing Hydrogen peroxide generation and cell death in the human gastric cancer cell line NUGC-4[J]. Free Radical Research, 2021, 55(3): 211-220.
Jing Y Z, Li S J, Sun Z J. Gas and gas-generating nanoplatforms in cancer therapy[J]. Journal of Materials Chemistry B, 2021, 9(41): 8541-8557.
Li Y, Li G, Suo L, et al. Recent advances in studies of molecular Hydrogen in the treatment of pancreatitis[J]. Life Sciences, 2021, 264: 118641.
Masuda H, Sato A, Miyata K, et al. Drinking molecular Hydrogen water is beneficial to cardiovascular function in diet-induced obesity mice[J]. Biology, 2021, 10(5): 364.
Nie C, Zou R, Pan S, et al. Hydrogen gas inhalation ameliorates cardiac remodelling and fibrosis by regulating NLRP3 inflammasome in myocardial infarction rats[J]. Journal of Cellular and Molecular Medicine, 2021, 25(18): 8997-9010.
Zerveas S, Kydonakis E, Mente M S, et al. Hydrogen gas as a central on-off functional switch of reversible metabolic arrest–New perspectives for biotechnological applications[J]. Journal of Biotechnology, 2021, 335: 9-18.
Hu D, Li D, Shigeta M, et al. Alleviation of the chronic stress response attributed to the antioxidant and anti-inflammatory effects of electrolyzed Hydrogen water[J]. Biochemical and Biophysical Research Communications, 2021, 535: 1-5.
Wei X, Chen J, Chen H, et al. Hydrogen-rich water ameliorates the toxicity induced by Ca (NO3) 2 excess through enhancing antioxidant capacities and re-establishing nitrate homeostasis in Brassica campestris spp. chinensis L. seedlings[J]. Acta Physiologiae Plantarum, 2021, 43(3): 1-12.
Xiao L, Mochizuki M, Nakahara T, Miwa N. Hydrogen-Generating Silica Material Prevents UVA-ray-Induced Cellular Oxidative Stress, Cell Death, Collagen Loss and Melanogenesis in Human Cells and 3D Skin Equivalents. Antioxidants (Basel). 2021 Jan 8;10(1):76.
Gong W, Xia C, He Q. Therapeutic gas delivery strategies[J]. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 2021: e1744.
Nogueira J E, Branco L G S. Recent advances in molecular Hydrogen research reducing exercise-induced oxidative stress and inflammation[J]. Current Pharmaceutical Design, 2021, 27(5): 731-736.
Nogueira J E, Amorim M R, Pinto A P, et al. Molecular Hydrogen downregulates acute exhaustive exercise-induced skeletal muscle damage[J]. Canadian journal of physiology and pharmacology, 2021, 99(8): 812-820.
Liu B, Xie Y, Chen J, et al. Protective effect of molecular Hydrogen following different routes of administration on D-Galactose-induced aging mice[J]. Journal of Inflammation Research, 2021, 14: 5541.
Truong S K, Katoh T, Mimuro S, et al. Inhalation of 2% Hydrogen improves survival rate and attenuates shedding of vascular endothelial glycocalyx in rats with heat stroke[J]. Shock, 2021, 56(4): 593-600.
Magliocca A, Fries M. Inhaled gases as novel neuroprotective therapies in the postcardiac arrest period[J]. Current opinion in critical care, 2021, 27(3): 255-260.
Zan R, Wang H, Ni J, et al. Multifunctional Magnesium Anastomosis Staples for Wound Closure and Inhibition of Tumor Recurrence and Metastasis[J]. ACS Biomaterials Science & Engineering, 2021, 7(11): 5269-5278.
Hirano S, Ichikawa Y, Sato B, et al. Potential therapeutic applications of Hydrogen in chronic inflammatory diseases: Possible inhibiting role on mitochondrial stress[J]. International journal of molecular sciences, 2021, 22(5): 2549.
Liu R, Peng Y, Lu L, et al. Near-infrared light-triggered nano-prodrug for cancer gas therapy[J]. Journal of Nanobiotechnology, 2021, 19(1): 1-23.
Fransson A E, Videhult Pierre P, Risling M, et al. Inhalation of molecular hydrogen, a rescue treatment for noise-induced hearing loss[J]. Frontiers in Cellular Neuroscience, 2021, 15: 192.
Qian L, Liu J, Ma W, et al. Hydrogen-rich water ameliorates murine chronic graft-versus-host disease through antioxidation[J]. Oxidative Medicine and Cellular Longevity, 2021, 2021.
Tong J, Zhang Y, Yu P, et al. Protective Effect of Hydrogen Gas on Mouse Hind Limb Ischemia-Reperfusion Injury[J]. Journal of Surgical Research, 2021, 266: 148-159.
Li T, Gao L, Zhang B, et al. Material-based engineering of bacteria for cancer diagnosis and therapy[J]. Applied Materials Today, 2021, 25: 101212.
Kubota M, Kawashima M, Inoue S, et al. Randomized, crossover clinical efficacy trial in humans and mice on tear secretion promotion and lacrimal gland protection by molecular hydrogen[J]. Scientific reports, 2021, 11(1): 1-9.
Wang L, Xie X, Ke B, et al. Recent advances on endogenous gasotransmitters in inflammatory dermatological disorders[J]. Journal of Advanced Research, 2021.
Jiang B, Li Y, Dai W, et al. Hydrogen-rich saline alleviates early brain injury through regulating of ER stress and autophagy after experimental subarachnoid hemorrhage[J]. Acta Cirúrgica Brasileira, 2021, 36.
Domoki F. Hydrogen-induced neuroprotection in neonatal hypoxic-ischemic encephalopathy[J]. Current Pharmaceutical Design, 2021, 27(5): 687-694.
Rosch M, Lucas K, Al-Gousous J, et al. Formulation and Characterization of an Effervescent Hydrogen-Generating Tablet[J]. Pharmaceuticals, 2021, 14(12): 1327.
Ohta S. Development of Hydrogen medicine and biology: potential for various applications in diverse fields[J]. Current Pharmaceutical Design, 2021, 27(5): 583-584.
Rochette L, Zeller M, Cottin Y, et al. Antitumor activity of protons and molecular hydrogen: underlying mechanisms[J]. Cancers, 2021, 13(4): 893.
Sada H, Egi H, Ide K, et al. Peritoneal lavage with hydrogen-rich saline can be an effective and practical procedure for acute peritonitis[J]. Surgery Today, 2021, 51(11): 1860-1871.
Niu J, Huang H, Pei J, et al. Research and development strategy for biodegradable magnesium-based vascular stents: a review[J]. Biomaterials Translational, 2021, 2(3): 236.
Shirakawa K, Kobayashi E, Ichihara G, et al. H2 Inhibits the Formation of Neutrophil Extracellular Traps[J]. JACC: Basic to Translational Science, 2022.
Timón R, Olcina G, González-Custodio A, et al. Effects of 7-day intake of Hydrogen-rich water on physical performance of trained and untrained subjects[J]. Biology of Sport, 2021, 38(2): 269.
Zhang L, Yu H, Tu Q, et al. New approaches for Hydrogen therapy of various diseases[J]. Current Pharmaceutical Design, 2021, 27(5): 636-649.
Hirano S, Ichikawa Y, Sato B, et al. Molecular Hydrogen as a potential clinically applicable radioprotective agent[J]. International Journal of Molecular Sciences, 2021, 22(9): 4566.
Hancock J T, LeBaron T W, May J, et al. Molecular Hydrogen: Is This a Viable New Treatment for Plants in the UK?[J]. Plants, 2021, 10(11): 2270.
Shin S S, Hwang M, Diaz-Arrastia R, et al. Inhalational gases for neuroprotection in traumatic brain injury[J]. Journal of neurotrauma, 2021, 38(19): 2634-2651.
Cheng P, Wang J, Zhao Z, et al. Molecular Hydrogen Increases Quantitative and Qualitative Traits of Rice Grain in Field Trials[J]. Plants, 2021, 10(11): 2331.
Zheng Y, Zhang Z, Wang T, et al. Photodriven nanoreactor with a hydrogen-insulin double act repairs diabetic wounds through Nrf2 pathway activation[J]. Chemical Engineering Journal, 2021, 425: 131800.
Li T, Sun T, Wang Y, et al. Molecular Hydrogen alleviates lung injury after traumatic brain injury: Pyroptosis and apoptosis[J]. European journal of pharmacology, 2022, 914: 174664.
Yang F, Lei Y, Liu R, et al. Hydrogen: Potential Applications in Solid Organ Transplantation[J]. Oxidative Medicine and Cellular Longevity, 2021, 2021.
Yin T, Becker L B, Choudhary R C, et al. Hydrogen gas with extracorporeal cardiopulmonary resuscitation improves survival after prolonged cardiac arrest in rats[J]. Journal of translational medicine, 2021, 19(1): 1-12.
Kayawake H, Chen-Yoshikawa T F, Saito M, et al. Protective effects of a hydrogen-rich preservation solution in a canine lung transplantation model[J]. The Annals of Thoracic Surgery, 2021, 111(1): 246-252.
Zhang H, Xie M, Chen H, et al. Gas-mediated cancer therapy[J]. Environmental Chemistry Letters, 2021, 19(1): 149-166.
Song L, Zhang Y, Zhu C, et al. Hydrogen-rich water partially alleviate inflammation, oxidative stress and intestinal flora dysbiosis in DSS-induced chronic ulcerative colitis mice[J]. Advances in Medical Sciences, 2022, 67(1): 29-38.
Zhang X, Xie F, Zhang Z, et al. Hydrogen Evolution and Absorption Phenomena in the Plasma Membrane of Vigna radiata and Capsicum annuum[J]. Journal of Plant Growth Regulation, 2022: 1-11.
Hu Y, Feng X, Chen J, et al. Hydrogenrich saline alleviates early brain injury through inhibition of necroptosis and neuroinflammation via the ROS/HO1 signaling pathway after traumatic brain injury[J]. Experimental and therapeutic medicine, 2022, 23(2): 1-10.
Lu H, Wang W, Kang X, et al. Hydrogen (H2) alleviates osteoarthritis by inhibiting apoptosis and inflammation via the JNK signaling pathway[J]. Journal of Inflammation Research, 2021, 14: 1387.
Aokage T, Seya M, Hirayama T, et al. The effects of inhaling Hydrogen gas on macrophage polarization, fibrosis, and lung function in mice with bleomycin-induced lung injury[J]. BMC pulmonary medicine, 2021, 21(1): 1-15.
Mizutani A, Endo A, Saito M, et al. Hydrogen-rich water reduced oxidative stress and renal fibrosis in rats with unilateral ureteral obstruction[J]. Pediatric Research, 2021: 1-8.
Liu Y, Wang Y, Xiao B, et al. pH-responsive delivery of H2 through ammonia borane-loaded mesoporous silica nanoparticles improves recovery after spinal cord injury by moderating oxidative stress and regulating microglial polarization[J]. Regenerative Biomaterials, 2021, 8(6): rbab058.
Hu Y, Wang P, Han K. Hydrogen attenuated inflammation response and oxidative in hypoxic ischemic encephalopathy via Nrf2 mediated the inhibition of NLRP3 and NF-κB[J]. Neuroscience, 2021.
Alharbi A A D, Ebine N, Nakae S, et al. Application of molecular Hydrogen as an antioxidant in responses to ventilatory and ergogenic adjustments during incremental exercise in humans[J]. Nutrients, 2021, 13(2): 459.
Sun R, Zhao N, Wang Y, et al. High concentration of Hydrogen gas alleviates Lipopolysaccharide-induced lung injury via activating Nrf2 signaling pathway in mice[J]. International Immunopharmacology, 2021, 101: 108198.
Hatae T, Miwa N. Electrolytic hydrogen-generating bottle supplies drinking water with free/combined chlorine and ozone repressed within safety standard under hydrogen-rich conditions[J]. Medical Gas Research, 2021, 11(2): 61.
Thakar S B, Ghorpade P N, Shaker B, et al. Gas-mediated cancer therapy combined with starvation therapy, ultrasound therapy, chemotherapy, radiotherapy, and photodynamic therapy: a review[J]. Environmental Chemistry Letters, 2021, 19(4): 2981-2993.
Saitoh Y, Yonekura N, Matsuoka D, et al. Molecular Hydrogen suppresses Porphyromonas gingivalis lipopolysaccharide-induced increases in interleukin-1 alpha and interleukin-6 secretion in human gingival cells[J]. Molecular and Cellular Biochemistry, 2022, 477(1): 99-104.
Li C, Cao Y, Kohei F, et al. Nano-bubble Hydrogen water: an effective therapeutic agent against inflammation related disease caused by viral infection in zebrafish model[J]. Virologica Sinica, 2022.
Li H, Yin Y, Liu J, et al. Hydrogen-rich water attenuates the radiotoxicity induced by tritium exposure in vitro and in vivo[J]. Journal of Radiation Research, 2021, 62(1): 34-45.
Botek M, Sládečková B, Krejčí J, et al. Acute hydrogen‐rich water ingestion stimulates cardiac autonomic activity in healthy females[J]. Acta Gymnica, 2021, 51(1): e2021. 009.
Köktürk M, Atalar M N, Odunkıran A, et al. Evaluation of the Hydrogen-rich water alleviation potential on mercury toxicity in earthworms using ATR-FTIR and LC–ESI–MS/MS spectroscopy[J]. Environmental Science and Pollution Research, 2021: 1-15.
Wang J, Cheng Q, Fang J, et al. A Preliminary Study on the Effect of Hydrogen Gas on Alleviating Early CCl4-Induced Chronic Liver Injury in Rats[J]. Antioxidants, 2021, 10(12): 1933.
Quan L, Zheng B, Zhou H. Protective effects of molecular Hydrogen on lung injury from lung transplantation[J]. Experimental Biology and Medicine, 2021, 246(12): 1410-1418.
Russell G , Nenov A . Oxy-hydrogen Gas: The Rationale Behind Its Use as a Novel and Sustainable Treatment for COVID-19 and Other Respiratory Diseases[J]. EMJ Innovation, 2021, 6(2).
Du J, Li J, Li R, et al. High concentration of Hydrogen ameliorates lipopolysaccharide-induced acute lung injury in a sirt1-dependent manner[J]. Respiratory physiology & neurobiology, 2022, 296: 103808.
Chinh N D, Haneul Y, Hieu N M, et al. pn-Heterojunction of the SWCNT/ZnO nanocomposite for temperature dependent reaction with hydrogen[J]. Journal of Colloid and Interface Science, 2021, 584: 582-591.
Liu L, Yang C, Qiu T, et al. Hydrogen alleviates acute lung injury induced by limb ischaemia/reperfusion in mice[J]. Life Sciences, 2021, 279: 119659.
Li K, Yin H, Duan Y, et al. Pre-inhalation of hydrogen-rich gases protect against caerulein-induced mouse acute pancreatitis while enhance the pancreatic Hsp60 protein expression[J]. BMC gastroenterology, 2021, 21(1): 1-10.
LeBaron T W, Kharman J, McCullough M. Effects of an H2-infused, Nitric Oxide-Producing Functional Beverage on Exercise and Cognitive Performance[J]. The Journal of Science and Medicine, 2021, 3(2): 1-15.
Carnovali M, Mariotti M, Banfi G. Molecular Hydrogen enhances osteogenesis in Danio rerio embryos[J]. Journal of Fish Biology, 2021, 98(5): 1471-1474.
Trinh T T, Fadriquela A, Lee K J, et al. Development of Alkaline Reduced Water Using High-Temperature-Roasted Mineral Salt and Its Antioxidative Effect in RAW 264.7 Murine Macrophage Cell Line[J]. Processes, 2021, 9(11): 1928.
Terasaki Y, Terasaki M, Shimizu A. Protective effects of Hydrogen against irradiation[J]. Current Pharmaceutical Design, 2021, 27(5): 679-686.
Tanaka Y, Xiao L, Miwa N. Hydrogen-rich bath with nano-sized bubbles improves antioxidant capacity based on oxygen radical absorbing and inflammation levels in human serum[J]. Medical gas research, 2022, 12(3): 91.
Zhang J, Feng X, Fan Y, et al. Molecular Hydrogen alleviates asthma through inhibiting IL-33/ILC2 axis[J]. Inflammation Research, 2021, 70(5): 569-579.
Russell G, Nenov A, Kisher H, et al. Molecular Hydrogen as Medicine: An Assessment of Administration Methods[J]. Hydrogen, 2021, 2(4): 444-460.
Nazarov E I, Khlusov I A, Noda M. Homeostatic and endocrine responses as the basis for systemic therapy with medical gases: ozone, xenon and molecular hydrogen[J]. Medical Gas Research, 2021, 11(4): 174.
Qi D D, Ding M Y, Wang T, et al. The Therapeutic Effects of Oral Intake of Hydrogen Rich Water on Cutaneous Wound Healing in Dogs[J]. Veterinary Sciences, 2021, 8(11): 264.
Cole A R, Sperotto F, DiNardo J A, et al. Safety of prolonged inhalation of Hydrogen gas in air in healthy adults[J]. Critical care explorations, 2021, 3(10).
Qiu X, Bajinka O, Wang L, et al. High-fat diet promotes epithelial-mesenchymal transition through enlarged growth of opportunistic pathogens and the intervention of saturated hydrogen[J]. American Journal of Translational Research, 2021, 13(6): 6016.
Htun Y, Nakamura S, Kusaka T. Hydrogen and therapeutic gases for neonatal hypoxic–ischemic encephalopathy: potential neuroprotective adjuncts in translational research[J]. Pediatric Research, 2021, 89(4): 753-759.
Danilova D A, Brichkin Y D, Medvedev A P, et al. Application of molecular Hydrogen in heart surgery under cardiopulmonary bypass[J]. Современные технологии в медицине, 2021, 13(1 (eng)).
Qiu P, Liu Y, Chen K, et al. Hydrogen-rich saline regulates the polarization and apoptosis of alveolar macrophages and attenuates lung injury via suppression of autophagy in septic rats[J]. Annals of Translational Medicine, 2021, 9(12).
Kaibori M , Kosaka H . Effect of Hydrogen Gas Inhalation on Patient QOL After Hepatectomy: Protocol for a Randomized Controlled Trial. 2021
Zhang Y, Liu H, Xu J, et al. Hydrogen Gas: A Novel Type of Antioxidant in Modulating Sexual Organs Homeostasis[J]. Oxidative Medicine and Cellular Longevity, 2021, 2021.
Kato S, Takada Y, Miwa N. Heat-retention effects of Hydrogen-rich water bath assessed by thermography for humans[J]. Journal of Thermal Biology, 2021, 95: 102805.
Han Q, Song Z W, Jia H Y, et al. Hydrogen gas post-conditioning attenuates early neuronal pyroptosis in a rat model of subarachnoid hemorrhage through the mitoK ATP signaling pathway[J]. Experimental and Therapeutic Medicine, 2021, 22(2).
Miura M, Imai K, Tsuda H, et al. Prenatal molecular Hydrogen administration ameliorates several findings in nitrofen-induced congenital diaphragmatic hernia[J]. International journal of molecular sciences, 2021, 22(17): 9500.
Hirano S, Yamamoto H, Ichikawa Y, et al. Molecular Hydrogen as a Novel Antitumor Agent: Possible Mechanisms Underlying Gene Expression[J]. International Journal of Molecular Sciences, 2021, 22(16): 8724.
赵鹏翔, 谢飞, 刘梦昱. 氢气生物医学研究进展[J]. 生物技术进展, 2021, 11(4): 503.
Jeong E S, Bajgai J, You I S, et al. Therapeutic Effects of Hydrogen Gas Inhalation on Trimethyltin-Induced Neurotoxicity and Cognitive Impairment in the C57BL/6 Mice Model[J]. International Journal of Molecular Sciences, 2021, 22(24): 13313.
Liang I, Ko W C, Hsu Y J, et al. The Anti-Inflammatory Effect of Hydrogen Gas Inhalation and Its Influence on Laser-Induced Choroidal Neovascularization in a Mouse Model of Neovascular Age-Related Macular Degeneration[J]. International journal of molecular sciences, 2021, 22(21): 12049.
Wang S T, Xu K F. Response to: Hydrogen therapy as an effective and novel adjuvant treatment against COVID-19[J]. QJM: An International Journal of Medicine, 2021, 114(1): 76-76.
Li Q, Xie F, Yi Y, et al. Hydroxyl-radical scavenging activity of Hydrogen does not significantly contribute to its biological function[J]. bioRxiv, 2021.
Panina E, Ivanov A, Petrov D. The condition of the hairline of Chinchilla lanigera after the introduction of a Hydrogen antioxidant into the diet[C]//BIO Web of Conferences. EDP Sciences, 2021, 36.
Rochette L, Zeller M, Cottin Y, et al. Antitumor Activity of Protons and Molecular Hydrogen: Underlying Mechanisms. Cancers 2021, 13, 893[J]. 2021.
Hancock J T, Russell G. Downstream Signalling from Molecular Hydrogen. Plants 2021, 10, 367[J]. 2021.
Panina E, Ivanov A, Petrov D, et al. Influence of molecular Hydrogen on behavioral adaptation of Сhinchilla lanigera taking into account gender factor in conditions of cage keeping[C]//BIO Web of Conferences. EDP Sciences, 2021, 36.
李悦娴, 秦树存, 张锦. 富氢水对小鼠脓毒症胰腺损伤的改善作用[J]. Tianjin Medical Journal, 2021, 49(8).
Chilicka K, Rogowska A M, Szyguła R. Effects of Topical Hydrogen Purification on Skin Parameters and Acne Vulgaris in Adult Women. Healthcare 2021, 9, 144[J]. 2021.
Zhang T, Wang F, Jiang G, et al. Anti-inflammatory Effects of Hydrogen in LPS-induced RAW264. 7 Cells via Inhibiting NF-κB and MAPKs Signaling Pathways[J]. 2021.
Chung M H, Ro J Y. The Medical Uses of Hydrogen[J]. Food Supplements and Biomaterials for Health, 2021, 1.
Chilicka K, Rogowska A M, Szyguła R. Effects of topical Hydrogen purification on skin parameters and acne vulgaris in adult women[C]//Healthcare. Multidisciplinary Digital Publishing Institute, 2021, 9(2): 144.
Xie K, Mao X, Lian N, et al. Hydrogen-Rich Medium Ameliorates Lipopolysaccharides-Induced Mitochondrial Fission and Dysfunction in Human Umbilical Vein Endothelial Cells (Huvecs) via Up-Regulating HO-1 Expression[J]. 2021.
Lu Z, Zhang T, Hu Y, et al. Molecular Hydrogen Attenuates High Hydrostatic Pressure-Induced Neuronal Cell Damage by Reversing Dysfunction of Mitochondrial Electron Transfer Chain[J]. 2021.
Aokage T, Seya M, Hirayama T, Nojima T, Iketani M, Ishikawa M, Terasaki Y, Taniguchi A, Miyahara N, Nakao A, Ohsawa I, Naito H. The effects of inhaling hydrogen gas on macrophage polarization, fibrosis, and lung function in mice with bleomycin-induced lung injury. BMC Pulm Med. 2021 Oct 31;21(1):339
Xie G, Liu Z, Wang J, et al. Effect of Hydrogen-rich water on Gut Microbiota in Mice With High-Fat Diet[J]. 2021.
Shogenova L V, Truong T T, Kryukova N O, et al. Hydrogen inhalation in rehabilitation program of the medical staff recovered from COVID-19[J]. Cardiovascular Therapy and Prevention, 2021, 20(6): 2986.
Fei W, Pang E, Hou L, et al. Hydrogen Enhanced the Myogenic Differentiation of Adipose Mesenchymal Stem Cells Through P38 MAPK Signaling Pathway[J]. 2021.
Li L, Yin Q, Zhang T, et al. Hydrogen Nanobubble Water Delays Petal Senescence and Prolongs the Vase Life of Cut Carnation (Dianthus caryophyllus L.) Flowers. Plants 2021, 10, 1662[J]. 2021.
Qi D D, Wang T, Hayat M A, et al. The Effects of Hydrogen-rich water on Skin Wound Healing in Dogs[J]. 2021.
Huang Y, Xiao F M, Tang W J, et al. Hydrogen inhalation promotes recovery of a patient in persistent vegetative state from intracerebral hemorrhage: A case report and literature review[J]. World Journal of Clinical Cases, 2022, 10(4): 1311-1319.
Xie F, Jiang X, Yi Y, et al. Effects of Long-Term Hydrogen Intervention on Plasma Metabolites and Gut Microbiome of Rats in Health Status[J]. 2021.
Kwon H J. Hydrogen’s Antiaging and Whitening Effects on Skin[J]. Turkish Journal of Computer and Mathematics Education (TURCOMAT), 2021, 12(5): 369-374.
Danilova D A, Skokova A A, Deryugina A V. Evaluation of pro-and antioxidant effects of molecular Hydrogen on experimental chronic heart failure induced rats[J]. Opera Medica et Physiologica, 2021, 8(1): 22-28.
Gu Q, Liu B, Xue J, et al. Effects of drinking Hydrogen-rich water in men at risk of peripheral arterial disease: a randomized placebo-controlled trial[J]. 2021.
Chang Y, Zhang Z, Bao X, et al. Hyperbaric Oxygen Combined With Hydrogen-rich Saline Protect Against Acute Lung Injury Induced by Lipopolysaccharide in Rat Model[J]. 2021.
赵学佳, 沈葹, 朱志玲, 等. 氢气在疾病治疗中的应用[J]. 临床药物治疗杂志, 2021, 19(2): 1-5.
何晋, 寻治铭, 谢飞, 等. 长期饮用富氢水对正常大鼠生理功能的影响[J]. 生物技术进展, 2021, 11(3): 353.
Chang Y , Zhang Z , Bao X , et al. Basic research on the effects of hyperbaric oxygen combined with hydrogen-rich saline on acute lung injury induced by lipopolysaccharide. 2021
Özer A, ARSLAN M, Comu F, et al. The Effect of Hydrogen-Rich Saline Solution on Erythrocyte Deformability in Lower Limb Ischemia Reperfusion Injury in Rats[J]. GAZI MEDICAL JOURNAL, 2021, 32.
Zhang L, Zhiwei W E I, Wei T A N, et al. Effects of Hydrogen on Storage Decay and Antioxidant System of Strawberry[J]. Agricultural Biotechnology (2164-4993), 2021, 10(4).
Dom A. Evaluation of the Daily Intake of 0.5 L of Water Saturated With Molecular Hydrogen for 21 Days in COVID-19 Patients Treated in Ambulatory Care[J]. 2021.
甲谷佳亮, 古我知成. 運動耐容能と呼気水素ガス濃度との関連性[J]. 川崎医療福祉学会誌, 2021, 31(1): 123-128.
寒川昌平, 松浦明日香, 須賀裕希, 等. 水素ガス吸入法による透析患者の酸化ストレスおよび CRP の低減[J]. 日本透析医学会雑誌, 2021, 54(9): 433-439.
池田安宏, 室谷里見, 佐藤和孝, 等. 水素/炭酸ガス含有飲用水の各種生体計測値への影響と安全性の検討[J]. 山口医学, 2021, 70(3): 109-118.
菅谷公男, 西島さおり, 嘉手川豪心, 等. 呼気中水素濃度と飲食物および泌尿器疾患との関連[J]. 日本泌尿器科学会雑誌, 2021, 112(1): 11-17.
李卫霞, 陈剑华, 郭旭丽, 等. 氢水对高脂高糖饲料喂养大鼠主要脏器和肝损伤的调节作用[J]. 生命科学研究, 25(3): 202-208.
Hydrogen: A Novel Treatment Strategy in Kidney Disease
Chaoqun L, Yuqi Z, Shi Z, et al. A Comparison of the Antioxidant Effects Between Hydrogen Gas Inhalation and Vitamin C Supplementation in Response to a 60-Min Treadmill Exercise in Rat Gastrocnemius Muscle[J]. Frontiers in Physiology, 2021: 1771.
Wang X, Tong B, Hui R, et al. The Role of Hyperthermia in Methamphetamine-Induced Depression-Like Behaviors: Protective Effects of Coral Calcium Hydride[J]. Frontiers in Molecular Neuroscience, 2021, 14.
Tian Y, Zhang Y, Wang Y, et al. Hydrogen, a Novel Therapeutic Molecule, Regulates Oxidative Stress, Inflammation, and Apoptosis[J]. Frontiers in physiology, 2021: 2281.
LeBaron J T H T W, Russell G, Hancock J T. Molecular Hydrogen: Redox Reactions and Possible Biological Interactions[J].
Li C, Zhao X, Gu X, et al. The Preventive Role of Hydrogen-rich water in Thioacetamide-Induced Cholangiofibrosis in Rat Assessed by Automated Histological Classification[J]. Frontiers in pharmacology, 2021: 1708.
Yu S, Lv Z B, Gao Z, et al. Hydrogen Promotes the M1 Macrophage Conversion During the Polarization of Macrophages in Necrotizing Enterocolitis[J]. Frontiers in pediatrics, 2021, 9.
Li Y, Wang Z, Wang Y, et al. Molecular Hydrogen: A Promising Adjunctive Strategy for COVID-19 treatment[J]. Frontiers in Medicine, 2021: 1830.
林哲也. 低酸素ストレスと心血管病[J].
髙野温. マイクロ流体チップ上でのマルチガスインキュベーションを用いた低酸素細胞培養システム[J].
Tanaka Y, Xiao L, Miwa N. Hydrogen-rich bath with nano-sized bubbles improves antioxidant capacity based on oxygen radical absorbing and inflammation levels in human serum. Med Gas Res. 2022 Jul-Sep;12(3):91-99.
Li R, Qu Y, Li X, et al. Molecular Hydrogen Attenuated N-methyl-N-Nitrosourea Induced Corneal Endothelial Injury by Upregulating Anti-Apoptotic Pathway[J]. Investigative Ophthalmology & Visual Science, 2021, 62(9): 2-2.
Yang H, Liu S, Du H, et al. Hydrogen Attenuates Myocardial Injury in Rats by Regulating Oxidative Stress and NLRP3 Inflammasome Mediated Pyroptosis[J]. International journal of medical sciences, 2021, 18(14): 3318.

上一篇：对老年性痴呆，氢气是上等抗氧化剂

下一篇：对氢医学误解的四假象

2021年氢医学生物学研究论文汇编

Qian L, Liu J, Ma W, et al. Hydrogen-rich water ameliorates murine chronic graft-versus-host disease through antioxidation[J]. Oxidative Medicine and Cellular Longevity, 2021, 2021.

Tong J, Zhang Y, Yu P, et al. Protective Effect of Hydrogen Gas on Mouse Hind Limb Ischemia-Reperfusion Injury[J]. Journal of Surgical Research, 2021, 266: 148-159.

Li T, Gao L, Zhang B, et al. Material-based engineering of bacteria for cancer diagnosis and therapy[J]. Applied Materials Today, 2021, 25: 101212.

Kubota M, Kawashima M, Inoue S, et al. Randomized, crossover clinical efficacy trial in humans and mice on tear secretion promotion and lacrimal gland protection by molecular hydrogen[J]. Scientific reports, 2021, 11(1): 1-9.

Wang L, Xie X, Ke B, et al. Recent advances on endogenous gasotransmitters in inflammatory dermatological disorders[J]. Journal of Advanced Research, 2021.

Jiang B, Li Y, Dai W, et al. Hydrogen-rich saline alleviates early brain injury through regulating of ER stress and autophagy after experimental subarachnoid hemorrhage[J]. Acta Cirúrgica Brasileira, 2021, 36.

Domoki F. Hydrogen-induced neuroprotection in neonatal hypoxic-ischemic encephalopathy[J]. Current Pharmaceutical Design, 2021, 27(5): 687-694.

Rosch M, Lucas K, Al-Gousous J, et al. Formulation and Characterization of an Effervescent Hydrogen-Generating Tablet[J]. Pharmaceuticals, 2021, 14(12): 1327.

Ohta S. Development of Hydrogen medicine and biology: potential for various applications in diverse fields[J]. Current Pharmaceutical Design, 2021, 27(5): 583-584.

Rochette L, Zeller M, Cottin Y, et al. Antitumor activity of protons and molecular hydrogen: underlying mechanisms[J]. Cancers, 2021, 13(4): 893.

Sada H, Egi H, Ide K, et al. Peritoneal lavage with hydrogen-rich saline can be an effective and practical procedure for acute peritonitis[J]. Surgery Today, 2021, 51(11): 1860-1871.

Niu J, Huang H, Pei J, et al. Research and development strategy for biodegradable magnesium-based vascular stents: a review[J]. Biomaterials Translational, 2021, 2(3): 236.

Shirakawa K, Kobayashi E, Ichihara G, et al. H2 Inhibits the Formation of Neutrophil Extracellular Traps[J]. JACC: Basic to Translational Science, 2022.

Timón R, Olcina G, González-Custodio A, et al. Effects of 7-day intake of Hydrogen-rich water on physical performance of trained and untrained subjects[J]. Biology of Sport, 2021, 38(2): 269.

Zhang L, Yu H, Tu Q, et al. New approaches for Hydrogen therapy of various diseases[J]. Current Pharmaceutical Design, 2021, 27(5): 636-649.

Hirano S, Ichikawa Y, Sato B, et al. Molecular Hydrogen as a potential clinically applicable radioprotective agent[J]. International Journal of Molecular Sciences, 2021, 22(9): 4566.

Hancock J T, LeBaron T W, May J, et al. Molecular Hydrogen: Is This a Viable New Treatment for Plants in the UK?[J]. Plants, 2021, 10(11): 2270.

Shin S S, Hwang M, Diaz-Arrastia R, et al. Inhalational gases for neuroprotection in traumatic brain injury[J]. Journal of neurotrauma, 2021, 38(19): 2634-2651.

Cheng P, Wang J, Zhao Z, et al. Molecular Hydrogen Increases Quantitative and Qualitative Traits of Rice Grain in Field Trials[J]. Plants, 2021, 10(11): 2331.

Zheng Y, Zhang Z, Wang T, et al. Photodriven nanoreactor with a hydrogen-insulin double act repairs diabetic wounds through Nrf2 pathway activation[J]. Chemical Engineering Journal, 2021, 425: 131800.

Li T, Sun T, Wang Y, et al. Molecular Hydrogen alleviates lung injury after traumatic brain injury: Pyroptosis and apoptosis[J]. European journal of pharmacology, 2022, 914: 174664.

Yang F, Lei Y, Liu R, et al. Hydrogen: Potential Applications in Solid Organ Transplantation[J]. Oxidative Medicine and Cellular Longevity, 2021, 2021.

Yin T, Becker L B, Choudhary R C, et al. Hydrogen gas with extracorporeal cardiopulmonary resuscitation improves survival after prolonged cardiac arrest in rats[J]. Journal of translational medicine, 2021, 19(1): 1-12.

Kayawake H, Chen-Yoshikawa T F, Saito M, et al. Protective effects of a hydrogen-rich preservation solution in a canine lung transplantation model[J]. The Annals of Thoracic Surgery, 2021, 111(1): 246-252.

Zhang H, Xie M, Chen H, et al. Gas-mediated cancer therapy[J]. Environmental Chemistry Letters, 2021, 19(1): 149-166.

Song L, Zhang Y, Zhu C, et al. Hydrogen-rich water partially alleviate inflammation, oxidative stress and intestinal flora dysbiosis in DSS-induced chronic ulcerative colitis mice[J]. Advances in Medical Sciences, 2022, 67(1): 29-38.

Zhang X, Xie F, Zhang Z, et al. Hydrogen Evolution and Absorption Phenomena in the Plasma Membrane of Vigna radiata and Capsicum annuum[J]. Journal of Plant Growth Regulation, 2022: 1-11.

Hu Y, Feng X, Chen J, et al. Hydrogenrich saline alleviates early brain injury through inhibition of necroptosis and neuroinflammation via the ROS/HO1 signaling pathway after traumatic brain injury[J]. Experimental and therapeutic medicine, 2022, 23(2): 1-10.

Lu H, Wang W, Kang X, et al. Hydrogen (H2) alleviates osteoarthritis by inhibiting apoptosis and inflammation via the JNK signaling pathway[J]. Journal of Inflammation Research, 2021, 14: 1387.

Aokage T, Seya M, Hirayama T, et al. The effects of inhaling Hydrogen gas on macrophage polarization, fibrosis, and lung function in mice with bleomycin-induced lung injury[J]. BMC pulmonary medicine, 2021, 21(1): 1-15.

Mizutani A, Endo A, Saito M, et al. Hydrogen-rich water reduced oxidative stress and renal fibrosis in rats with unilateral ureteral obstruction[J]. Pediatric Research, 2021: 1-8.

Liu Y, Wang Y, Xiao B, et al. pH-responsive delivery of H2 through ammonia borane-loaded mesoporous silica nanoparticles improves recovery after spinal cord injury by moderating oxidative stress and regulating microglial polarization[J]. Regenerative Biomaterials, 2021, 8(6): rbab058.

Hu Y, Wang P, Han K. Hydrogen attenuated inflammation response and oxidative in hypoxic ischemic encephalopathy via Nrf2 mediated the inhibition of NLRP3 and NF-κB[J]. Neuroscience, 2021.

Alharbi A A D, Ebine N, Nakae S, et al. Application of molecular Hydrogen as an antioxidant in responses to ventilatory and ergogenic adjustments during incremental exercise in humans[J]. Nutrients, 2021, 13(2): 459.

Sun R, Zhao N, Wang Y, et al. High concentration of Hydrogen gas alleviates Lipopolysaccharide-induced lung injury via activating Nrf2 signaling pathway in mice[J]. International Immunopharmacology, 2021, 101: 108198.

Hatae T, Miwa N. Electrolytic hydrogen-generating bottle supplies drinking water with free/combined chlorine and ozone repressed within safety standard under hydrogen-rich conditions[J]. Medical Gas Research, 2021, 11(2): 61.

Thakar S B, Ghorpade P N, Shaker B, et al. Gas-mediated cancer therapy combined with starvation therapy, ultrasound therapy, chemotherapy, radiotherapy, and photodynamic therapy: a review[J]. Environmental Chemistry Letters, 2021, 19(4): 2981-2993.

Saitoh Y, Yonekura N, Matsuoka D, et al. Molecular Hydrogen suppresses Porphyromonas gingivalis lipopolysaccharide-induced increases in interleukin-1 alpha and interleukin-6 secretion in human gingival cells[J]. Molecular and Cellular Biochemistry, 2022, 477(1): 99-104.

Li C, Cao Y, Kohei F, et al. Nano-bubble Hydrogen water: an effective therapeutic agent against inflammation related disease caused by viral infection in zebrafish model[J]. Virologica Sinica, 2022.

Li H, Yin Y, Liu J, et al. Hydrogen-rich water attenuates the radiotoxicity induced by tritium exposure in vitro and in vivo[J]. Journal of Radiation Research, 2021, 62(1): 34-45.

Botek M, Sládečková B, Krejčí J, et al. Acute hydrogen‐rich water ingestion stimulates cardiac autonomic activity in healthy females[J]. Acta Gymnica, 2021, 51(1): e2021. 009.

Köktürk M, Atalar M N, Odunkıran A, et al. Evaluation of the Hydrogen-rich water alleviation potential on mercury toxicity in earthworms using ATR-FTIR and LC–ESI–MS/MS spectroscopy[J]. Environmental Science and Pollution Research, 2021: 1-15.

Wang J, Cheng Q, Fang J, et al. A Preliminary Study on the Effect of Hydrogen Gas on Alleviating Early CCl4-Induced Chronic Liver Injury in Rats[J]. Antioxidants, 2021, 10(12): 1933.

Quan L, Zheng B, Zhou H. Protective effects of molecular Hydrogen on lung injury from lung transplantation[J]. Experimental Biology and Medicine, 2021, 246(12): 1410-1418.

Russell G , Nenov A . Oxy-hydrogen Gas: The Rationale Behind Its Use as a Novel and Sustainable Treatment for COVID-19 and Other Respiratory Diseases[J]. EMJ Innovation, 2021, 6(2).

Du J, Li J, Li R, et al. High concentration of Hydrogen ameliorates lipopolysaccharide-induced acute lung injury in a sirt1-dependent manner[J]. Respiratory physiology & neurobiology, 2022, 296: 103808.

Chinh N D, Haneul Y, Hieu N M, et al. pn-Heterojunction of the SWCNT/ZnO nanocomposite for temperature dependent reaction with hydrogen[J]. Journal of Colloid and Interface Science, 2021, 584: 582-591.

Liu L, Yang C, Qiu T, et al. Hydrogen alleviates acute lung injury induced by limb ischaemia/reperfusion in mice[J]. Life Sciences, 2021, 279: 119659.

Li K, Yin H, Duan Y, et al. Pre-inhalation of hydrogen-rich gases protect against caerulein-induced mouse acute pancreatitis while enhance the pancreatic Hsp60 protein expression[J]. BMC gastroenterology, 2021, 21(1): 1-10.

LeBaron T W, Kharman J, McCullough M. Effects of an H2-infused, Nitric Oxide-Producing Functional Beverage on Exercise and Cognitive Performance[J]. The Journal of Science and Medicine, 2021, 3(2): 1-15.

Carnovali M, Mariotti M, Banfi G. Molecular Hydrogen enhances osteogenesis in Danio rerio embryos[J]. Journal of Fish Biology, 2021, 98(5): 1471-1474.

Trinh T T, Fadriquela A, Lee K J, et al. Development of Alkaline Reduced Water Using High-Temperature-Roasted Mineral Salt and Its Antioxidative Effect in RAW 264.7 Murine Macrophage Cell Line[J]. Processes, 2021, 9(11): 1928.

Terasaki Y, Terasaki M, Shimizu A. Protective effects of Hydrogen against irradiation[J]. Current Pharmaceutical Design, 2021, 27(5): 679-686.

Tanaka Y, Xiao L, Miwa N. Hydrogen-rich bath with nano-sized bubbles improves antioxidant capacity based on oxygen radical absorbing and inflammation levels in human serum[J]. Medical gas research, 2022, 12(3): 91.

Zhang J, Feng X, Fan Y, et al. Molecular Hydrogen alleviates asthma through inhibiting IL-33/ILC2 axis[J]. Inflammation Research, 2021, 70(5): 569-579.

Russell G, Nenov A, Kisher H, et al. Molecular Hydrogen as Medicine: An Assessment of Administration Methods[J]. Hydrogen, 2021, 2(4): 444-460.

Nazarov E I, Khlusov I A, Noda M. Homeostatic and endocrine responses as the basis for systemic therapy with medical gases: ozone, xenon and molecular hydrogen[J]. Medical Gas Research, 2021, 11(4): 174.

Qi D D, Ding M Y, Wang T, et al. The Therapeutic Effects of Oral Intake of Hydrogen Rich Water on Cutaneous Wound Healing in Dogs[J]. Veterinary Sciences, 2021, 8(11): 264.

Cole A R, Sperotto F, DiNardo J A, et al. Safety of prolonged inhalation of Hydrogen gas in air in healthy adults[J]. Critical care explorations, 2021, 3(10).

Qiu X, Bajinka O, Wang L, et al. High-fat diet promotes epithelial-mesenchymal transition through enlarged growth of opportunistic pathogens and the intervention of saturated hydrogen[J]. American Journal of Translational Research, 2021, 13(6): 6016.

Htun Y, Nakamura S, Kusaka T. Hydrogen and therapeutic gases for neonatal hypoxic–ischemic encephalopathy: potential neuroprotective adjuncts in translational research[J]. Pediatric Research, 2021, 89(4): 753-759.

Danilova D A, Brichkin Y D, Medvedev A P, et al. Application of molecular Hydrogen in heart surgery under cardiopulmonary bypass[J]. Современные технологии в медицине, 2021, 13(1 (eng)).

Qiu P, Liu Y, Chen K, et al. Hydrogen-rich saline regulates the polarization and apoptosis of alveolar macrophages and attenuates lung injury via suppression of autophagy in septic rats[J]. Annals of Translational Medicine, 2021, 9(12).

Kaibori M , Kosaka H . Effect of Hydrogen Gas Inhalation on Patient QOL After Hepatectomy: Protocol for a Randomized Controlled Trial. 2021

Zhang Y, Liu H, Xu J, et al. Hydrogen Gas: A Novel Type of Antioxidant in Modulating Sexual Organs Homeostasis[J]. Oxidative Medicine and Cellular Longevity, 2021, 2021.

Kato S, Takada Y, Miwa N. Heat-retention effects of Hydrogen-rich water bath assessed by thermography for humans[J]. Journal of Thermal Biology, 2021, 95: 102805.

Han Q, Song Z W, Jia H Y, et al. Hydrogen gas post-conditioning attenuates early neuronal pyroptosis in a rat model of subarachnoid hemorrhage through the mitoK ATP signaling pathway[J]. Experimental and Therapeutic Medicine, 2021, 22(2).

Miura M, Imai K, Tsuda H, et al. Prenatal molecular Hydrogen administration ameliorates several findings in nitrofen-induced congenital diaphragmatic hernia[J]. International journal of molecular sciences, 2021, 22(17): 9500.

Hirano S, Yamamoto H, Ichikawa Y, et al. Molecular Hydrogen as a Novel Antitumor Agent: Possible Mechanisms Underlying Gene Expression[J]. International Journal of Molecular Sciences, 2021, 22(16): 8724.

赵鹏翔, 谢飞, 刘梦昱. 氢气生物医学研究进展[J]. 生物技术进展, 2021, 11(4): 503.

Jeong E S, Bajgai J, You I S, et al. Therapeutic Effects of Hydrogen Gas Inhalation on Trimethyltin-Induced Neurotoxicity and Cognitive Impairment in the C57BL/6 Mice Model[J]. International Journal of Molecular Sciences, 2021, 22(24): 13313.

Liang I, Ko W C, Hsu Y J, et al. The Anti-Inflammatory Effect of Hydrogen Gas Inhalation and Its Influence on Laser-Induced Choroidal Neovascularization in a Mouse Model of Neovascular Age-Related Macular Degeneration[J]. International journal of molecular sciences, 2021, 22(21): 12049.

Wang S T, Xu K F. Response to: Hydrogen therapy as an effective and novel adjuvant treatment against COVID-19[J]. QJM: An International Journal of Medicine, 2021, 114(1): 76-76.

Li Q, Xie F, Yi Y, et al. Hydroxyl-radical scavenging activity of Hydrogen does not significantly contribute to its biological function[J]. bioRxiv, 2021.

Panina E, Ivanov A, Petrov D. The condition of the hairline of Chinchilla lanigera after the introduction of a Hydrogen antioxidant into the diet[C]//BIO Web of Conferences. EDP Sciences, 2021, 36.

Rochette L, Zeller M, Cottin Y, et al. Antitumor Activity of Protons and Molecular Hydrogen: Underlying Mechanisms. Cancers 2021, 13, 893[J]. 2021.

Hancock J T, Russell G. Downstream Signalling from Molecular Hydrogen. Plants 2021, 10, 367[J]. 2021.

Panina E, Ivanov A, Petrov D, et al. Influence of molecular Hydrogen on behavioral adaptation of Сhinchilla lanigera taking into account gender factor in conditions of cage keeping[C]//BIO Web of Conferences. EDP Sciences, 2021, 36.

李悦娴, 秦树存, 张锦. 富氢水对小鼠脓毒症胰腺损伤的改善作用[J]. Tianjin Medical Journal, 2021, 49(8).