到底有多少篇氢医学研究论文，这不是一个容易回答的问题。

主要原因是，1，论文每天都在更新，这是一个动态的数值，你即使现在搞清楚了，以后仍然有可能会不准确。2、哪些属于医学研究论文，这也是个没有标准答案的问题。有一些非常重要的观点，就是只有看法，但没有具体研究证据，算不算？有更多相关研究论文综述，算不算？3、和医学相关的生物学研究，例如对微生物，真菌，甚至植物的效应。一般不认为是医学研究，但这些研究对于理解氢气的生物医学效应，了解整个领域的研究进展，都是非常重要的。

但是总结和整理氢气医学研究论文，对于全面了解氢医学研究进展，是非常重要的工作。尤其是对下游从事氢健康产品推广的企业，全面掌握这方面的信息更为重要。作为氢健康企业，本应该在这方面投入一定资源，随时整理氢医学研究文献。根据我的观察，国内很少有企业在这方面有系统性工作。日本Miz公司是这方面非常值得让人尊敬的企业，一直在这方面非常重视，不仅有自己的文献汇编，而且经常进行更新。更重要的是，他们把整理的资料在网上公布，这大大方便了大家。Miz公司的氢医学文献目录有几个突出几个特点是，1，只收录医学相关文献，2 只收录原始文献，3，按照疾病、使用方法、研究类型等进行了分类。

我主要参考该公司的氢医学文献目录，并对文章题目的核心含义进行中文解释，以方便大家使用。对文献按照第一作者的英文字母顺序排列给大家介绍。

氢气医学原创文献介绍 A

氢气医学效应文献B

1. 1. Cai J, Kang Z, Liu WW, et al (2008): Hydrogen therapy reduced apoptosis in neonatal hypoxia-ischemia rat model. Neurosci Lett, 441: 167-172. 氢气治疗新生儿脑缺血和细胞凋亡的关系，是我们的第一篇研究论文

2. 2. Cai J, Kang Z, Liu K, et al (2009): Neuroprotective effects of hydrogen saline in neonatal hypoxia-ischemia rat model. Brain Res, 1256: 129-137. 氢气盐水对新生儿脑缺血保护作用，我们的第二篇研究论文

3. 3. Cai WW, Zhang MH, Yu YS, et al (2013): Treatment with hydrogen molecule alleviates TNFα-indiced cell injury in osteoblast. Mol Cell Biochem, 373: 1-9. 氢气对成骨细胞损伤的保护作用

4. 4. Cardinal JS, Zhan J, Wang Y, et al (2010): Oral hydrogen water prevents chronic allograft nephropathy in rats. Kidney Int, 77: 101-109. 氢气水对慢性移植后肾病的预防作用

5. 5. Cejka C, Kossl J, Hermankova B, et al (2017a): Molecular hydrogen effectively heals alkali-induced cornea via suppression of oxidative stress. Oxi Med Cell Longev, Article ID 8906027. 氢气对碱溶液导致的角膜损伤的保护作用

6. 6. Cejka C, Kossl J, Hermankova B, et al (2017b): Therapeutic effect of molecular hydrogen in corneal UVB-induced oxidative stress and corneal photodamage. Sci Rep., 7:18017.氢气对紫外线诱导的角膜损伤

7. 7. Cejka C, Kossl J, Holan V, et al (2020): An immunohistochemical study of the increase in antioxidant capacity of corneal epithelial cells by molecular hydrogen, leading to the suppression of alkali-induced oxidative stress. Oxid Med Cell Longev, 2020: Article ID7435260.  氢分子增加角膜上皮细胞抗氧化能力，抑制碱诱导角膜损伤后氧化应激的免疫组化研究。

8. 8. Choi KS, Kim HJ, Do SH, et al (2018): Neuroprotective effects of hydrogen inhalation in an experimental rat intracerebral hemorrhage model. Brain Res Bull, 142: 122-128. 氢气吸入对实验性脑出血神经保护的研究

9. 9. Chen C, Chen Q, Mao Y, et al (2010a): Hydrogen-rich saline protects against spinal cord injury in rats. Neurochem Res. 35: 1111-1118. 氢气盐水对脊髓损伤的保护作用。

10. 10. Chen CH, Manaenko A, Zhan Y, et al (2010b): Hydrogen gas reduced acute hyperglycemia-enhanced hemorrhagic transformation in a focal ischemia rat model. Neuroscience. 169: 402-414. 高血糖可诱导脑缺血后出血，氢气能减少这种特定脑损伤

11. 11. Chen F, Xiong J, Guo W, et al (2013): Suppression of experimental abdominal aortic aneurysm by saturated hydrogen saline: a preliminary study with rats. Zhonghua Wai Ke Za Zhi, 51: 437-441. (in Chinese). 氢气盐水对实验性腹主动脉瘤的抑制作用研究，中文

12. 12. Chen F, Zhang T, Xiong J, et al (2014): Suppression of abdominal aortic aneurysm by hydrogen through chemokine-like factor1. Zhonghua Yi Xue Za Zhi, 94: 59-61. (in Chinese). 氢气通过炎症因子抑制腹部动脉瘤

13. 13. Chen G, Chen B, Dai C, et al (2017): Hydrogen inhalation is superior to mild hypothermia for improving neurological outcome and survival in a cardiac arrest model of spontaneously hypertensive rat. Shock 2017 Dec 26. doi: 10.1097/SHK. 0000000000001092. [Epub ahead of print]. 氢气吸入对心脏骤停后脑损伤保护比亚低温治疗更有效

14. 14. Chen G, Li J, Wang J, et al (2019): Inhaling hydrogen ameliorates early postresuscitation EEG characteristics in an asphyxial cardiac arrest rat model. Biomed Res Int. Article ID 6410159. 氢气吸入对心脏骤停后早期脑电图特征的影响

15. 15. Chen H, Sun YP, Li Y, et al (2010c): Hydrogen-rich saline ameliorates the severity of l-arginine-induced acute pancreatitis in rats. Biochem Biophys Res Commun. 393: 308-313. 氢气盐水对急性胰腺炎的治疗作用

16. 16. Chen H, Sun YP, Hu PF, et al (2011): The effects of hydrogen-rich saline on the contractile and structural changes of intestine induced by ischemia-reperfusion in rats. J Surg Res, 167: 316-322. 富氢生理盐水对大鼠缺血-再灌注后肠收缩及结构变化的影响

17. 17. Chen H, Zhou C, Xie K, et al (2019): Hydrogen-rich saline alleviated the hyperpathia and microglia activation via autophagy mediated inflammasome inactivation in neuropathic pain rats. Neuroscience, 421: 17-30. 氢气盐水对通过自噬介导的炎症小体失活减轻大鼠神经性疼痛

18. 18. Chen HG, Xie KL, Han HZ, et al (2013): Heme oxygenase-1 mediates the anti-inflammatory effect of molecular hydrogen in LPS stimulated RAW 264.7 macrophages. Int J Surg. 11:1060-1066. 氢气对内毒素诱导巨噬细胞炎症反应对抗作用

19. 19. Chen J, Zhang H, Hu J, et al (2017): Hydrogen-Rich Saline Alleviates Kidney Fibrosis Following AKI and Retains Klotho Expression.Front Pharmacol., 8:499.氢气盐水对肾脏纤维化的预防作用

20. 20. Chen JB, Kong XF, Lv YY, et al (2019): “Real world survey” of hydrogen-controlled cancer: a follow-up report of 82 advanced cancer patients. Med Gas Res, 9 (3): 115-121. 82例晚期癌症患者氢气控癌的真实世界研究

21. 21. Chen JB, Kong XF, Qian W, et al (2020): Two weeks of hydrogen inhalation can significantly reverse adaptive and innate immune system senescence patients with advanced non-small cell lung cancer: a self-controlled study. Med Gas Res, 10: 149-154. 14天氢气吸入对非小细胞肺癌晚期患者的先天免疫和获得性免疫功能的显著影响。

22. 22. Chen JB, Kong XF, Mu F (2021): High-flow hydrogen inhalation might suppresses the immune function of middle-aged participants: a self-controlled study. Med Gas Res, 11: 12-17. 氢气吸入对正常中年人免疫功能的影响

23. 23. Chen J, Mu F, Lu T, et al (2019c): Brain metastases completely disappear in non-small cell lung cancer using hydrogen gas inhalation: A case report. Onco Target Ther. 12: 11145-11151. 氢气吸入后非小细胞肺癌脑转移完全消失

24. 24. Chen K, Wang N, Diao Y, et al (2017): Hydrogen-Rich Saline Attenuates Brain Injury Induced by Cardiopulmonary Bypass and Inhibits Microvascular Endothelial Cell Apoptosis Via the PI3K/Akt/GSK3β Signaling Pathway in Rats. Cell Physiol Biochem. 43(4):1634-1647. 氢气盐水对脑损伤的治疗作用，体外循环，内皮细胞损伤，细胞凋亡和信号通路研究

25. 25. Chen K, Sun Y, Diao Y, et al (2018): Hydrogen-rich solution attenuates myocardial injury caused by cardiopulmonary bypass in rats via the Janus-activated kinase 2/signal transducer and activator of transcription 3 signaling pathway. Oncol Lett, 16: 167-178. 氢气水对心肺旁路诱导的心脏损伤作用和信号通路研究

26. 26. Chen L, Yu N, Lu Y, et al (2014): Hydrogen-saturated saline protects intensive narrow band noise-induced hearing loss in guinea pigs through an antioxidant effect. PLoS One. 9 (6):e100774. 氢气盐水对噪声性耳聋的保护作用

27. 27. Chen L, Chao Y, Cheng P, et al (2019): UPLC-QTOF/MS-based metabolomics reveals the protective mechanism of hydrogen on mice with ischemic stroke. Neurochem Res, 44: 1950-1963.  氢气对脑缺血的代谢组研究

28. 28. Chen Q, Chen P, Zhou S, et al (2013): Hydrogen-rich saline attenuated neuropathic pain by reducing oxidative stress. Can J Neurol Sci 40: 857-863. 氢气盐水治疗神经疼痛的研究

29. 29. Chen S, Jiang W (2015): Effect of hydrogen injected subcutaneously on testicular tissues of rats exposed to cigarette smoke. Int J Clin Exp Med. 8: 5565-5570. 氢气皮下注射对香烟烟雾诱导睾丸组织的保护作用

30. 30. Chen T, Tao Y, Yan W, et al (2016): Protective effects of hydrogen-rich saline against N-methyl-N-nitrosourea-induced photoreceptor degeneration. Exp Eye Res, 148: 65-73. 富氢生理盐水对眼睛药物诱导光感受器退化的保护作用

31. 31. Chen JB, Pan ZB, Du DM, et al (2019a): Hydrogen gas therapy shrinkage of metastatic gallbladder cancer: A case report. World J Clin Cases. 7: 2065-2074. 氢疗法治疗转移性胆囊癌1例。

32. 32. Chen J, Mu F, Lu T, et al (2019b): A gallbladder carcinoma patient with pseudo-progressive remission after hydrogen inhalation. Onco Targets Ther, 12: 8645-8651. 一例胆囊癌患者吸入氢后伪进行性缓解。

33. 33. Chen JB, Kong XF, Mu F, et al (2020): Hydrogen therapy can be used to control tumor progression and alleviate the adverse events of medications in patients with advanced non-small cell lung cancer. Med Gas Res, 10: 75-80. 氢气吸入疗法用于控制晚期非小细胞肺癌患者的肿瘤进展和减轻药物不良事件。

34. 34. Chen JB, Kong XF, Qian W, et al (2020): Two weeks of hydrogen inhalation can significantly reverse adaptive and innate immune system senescence patients with advanced non-small cell lung cancer: a self-controlled study. Med Gas Res, 10: 149-154. 两周的氢吸入显著逆转晚期非小细胞肺癌患者的适应性和先天免疫系统衰老。自我对照研究

35. 35. Chen X, Liu Q, Wang D, et al (2015): Protective effects of hydrogen-rich saline on rats with smoke inhalation injury. Oxid Med Cell Longev. 2015:106836. doi: 10.1155/2015/106836. Epub 2015 May 21.富氢生理盐水对烟雾吸入性损伤大鼠的保护作用

36. 36. Chen X, Cui J, Zhai X, et al (2018): Inhalation of hydrogen of different concentrations ameliorates spinal cord injury in mice by protecting spinal cord neurons from apoptosis, oxidative injury and mitochondrial structure damages. Cell Physiol Biochem. 47: 176-190. 不同浓度氢吸入可改善小鼠脊髓损伤，保护脊髓神经元凋亡、氧化损伤和线粒体结构损伤

37. 37. Chen Y, Jiang J, Miao H, et al (2013): Hydrogen-rich saline attenuates vascular smooth muscle cell proliferation and neointimal hyperplasia by inhibiting reactive oxygen species production and inactivating the Ras-ERK1/2-MEK1/2 and Akt pathways. Int J Mol Med, 31: 597-606. 氢气盐水对血管平滑肌增殖的抑制作用，对血管内膜增生的预防作用，抗氧化等信号通路研究

38. 38. Chen Y, Chen H, Xie K, et al (2015): H2 Treatment attenuated pain behavior and cytokine release through the HO-1/CO pathway in a rat model of neuropathic pain. Inflammation. 38:1835-1846. 氢气对神经性疼痛的治疗作用，细胞因子和一氧化碳通路研究

39. 39. Chen Y, Zong C, Jia J, et al (2020): A study on the protective effect of molecular hydrogen on osteoradionecrosis of the jaw in rats. Int J Oral Maxillofac Surg, 2020 May 22; S0901-5027 (20) 30156-9. doi: 10. 1016/j. ijom. 2020.04.011. Online ahead of print. 分子氢对大鼠放射性颌骨坏死保护作用的研究

40. 40. Cheng S, Peng L, Xu B, et al (2020): Protective effects of hydrogen-rich water against cartilage damage in a rat model of osteoarthritis by inhibiting oxidative stress, matrix catabolism, and apoptosis. Med Sci Monit. 2020 Jan 12;26: e920211. 富氢水通过抑制氧化应激、基质分解代谢和细胞凋亡对骨关节炎大鼠模型软骨损伤的保护作用

41. 41. Chi J, Li Z, Hong X, et al (2018): Inhalation of hydrogen attenuates progression of chronic heart failure via suppression of oxidative stress and P53 related to apoptosis pathway in rats. Front Physiol, 9: 1026. 氢气吸入对慢性心脏衰竭，通过抗氧化和P53 相关细胞凋亡通路

42. 42. Chu YY, Hua N, Ru YS, et al (2017): The protection of hydrogen-rich saline on a rat dry eye model induced by scopolamine hydrobromide. Zhonghua Yan Ke Za Zhi, 53: 363-372. (in Chinese). 氢气盐水对兔子干眼病的治疗作用（中文）

43. 43. Chuai Y, Zhao L, Ni J, et al (2011): A possible prevention strategy of radiation pneumonitis: combine radiotherapy with aerosol inhalation of hydrogen-rich solution. Med Sci Monit, 17: 1-4. 辐射肺损伤预防策略：放疗结合富氢溶液雾化吸入

44. 44. Chuai Y, Gao F, Li B, et al (2012a): Hydrogen-rich saline attenuates radiation-induced male germ cell loss in mice through reducing hydroxyl radicals. Biochem J, 442: 49-56. 氢气生理盐水对辐射诱导精子数量丢失的预防作用，羟基自由基中和效应

45. 45. Carnovali M, Mariotti M, Banfi G (2021): Molecular hydrogen enhances osteogenesis in Danio rerio embryos. J Fish Biol. 2021. Jan 6. doi: 10. 1111/jfb. 14670. Online ahead of print. 氢气对斑马鱼胚胎骨再生的促进作用

46. 46. Cauai Y, Shen J, Qian L, et al (2012b): Hydrogen-rich saline protects spermatogenesis and hematopoiesis in irradiated BALB/c mice. Med Sci Monit, 18: BR89-94. 氢气盐水保护辐射后精子再生和骨髓造血功能

47. 47. Cole AR, Perry DA, Raza A, et al (2019): Perioperatively inhaled hydrogen gas diminishes neurologic injury following experimental circulatory arrest in swine. JACC Basic Transl Sci, 4: 176-187. 氢气吸入对猪血液循环停导致的神经损伤的保护作用

48. 48. Cui J, Chen X, Zhai X, et al (2016): Inhalation of water electrolysis-derived hydrogen ameliorates cerebral ischemia-perfusion injury in rats – A possible new hydrogen resource for clinical use. Neuroscience, 335: 232-241. 电解水制作氢气吸入对脑缺血再灌注损伤的保护作用

49. 49. Cui Y, Zhang H, Ji M, et al (2014): Hydrogen-rich saline attenuates neuronal ischemia-reperfusion injury by protecting mitochondrial function in rats. J Sur Res, 2014 May 24. pii: S0022-4804(14)00529-0. doi: 10. 1016/j. jss. 2014. 05. 060. [Epub ahead of print]. 氢气盐水对缺血再灌注神经损伤的保护，线粒体功能相关