到底有多少篇氢医学研究论文，这不是一个容易回答的问题。

主要原因是，1，论文每天都在更新，这是一个动态的数值，你即使现在搞清楚了，以后仍然有可能会不准确。2、哪些属于医学研究论文，这也是个没有标准答案的问题。有一些非常重要的观点，就是只有看法，但没有具体研究证据，算不算？有更多相关研究论文综述，算不算？3、和医学相关的生物学研究，例如对微生物，真菌，甚至植物的效应。一般不认为是医学研究，但这些研究对于理解氢气的生物医学效应，了解整个领域的研究进展，都是非常重要的。

但是总结和整理氢气医学研究论文，对于全面了解氢医学研究进展，是非常重要的工作。尤其是对下游从事氢健康产品推广的企业，全面掌握这方面的信息更为重要。作为氢健康企业，本应该在这方面投入一定资源，随时整理氢医学研究文献。根据我的观察，国内很少有企业在这方面有系统性工作。日本Miz公司是这方面非常值得让人尊敬的企业，一直在这方面非常重视，不仅有自己的文献汇编，而且经常进行更新。更重要的是，他们把整理的资料在网上公布，这大大方便了大家。Miz公司的氢医学文献目录有几个突出几个特点是，1，只收录医学相关文献，2 只收录原始文献，3，按照疾病、使用方法、研究类型等进行了分类。

我主要参考该公司的氢医学文献目录，并对文章题目的核心含义进行中文解释，以方便大家使用。对文献按照第一作者的英文字母顺序排列给大家介绍。

• Kagawa A, Katsura K, Mizumoto M, et al (2012): Influence of hydrogen discharged from palladium base hydrogen storage alloys on cancer cells. Materials Science Forum, 706-709: 520-525. 遗漏文献 释氢气钯镍合金抗癌细胞学研究

• Kajisa T, Yamaguchi T, Hu A, et al (2017): Hydrogen water ameliorates the severity of atopic dermatitis-like lesions and decreases interleukin-1β, interleukin-33, and mast cell infiltration in NC/Nga mice. Saudi Med J.; 38(9): 928–933. 氢水改善小鼠特异性皮炎机制，降低细胞因子和肥大细胞浸润

• Kamimura N, Ichimiya H, Iuchi K, et al (2016): Molecular hydrogen stimulates the gene expression of transcriptional coactivator PGC- 1α to enhance fatty acid metabolism. Aging Mechanisms Disease, 2: 16008. 氢气通过调节 PGC- 1α同激活基因表达提高脂肪酸代谢

• Kato R, Nomura A, Sakamoto A, et al (2014): Hydrogen gas attenuates embroyonic gene expression and prevents left ventricular remodeling induced by intermittent hypoxia in cardiomyopathic hamsters. Am J Physiol Heart Circ Physiol, 2014 Oct 3; ajheart. 00228. 2014. doi: 10. 1152/ajpheart. 00228. 2014. 氢气对胚胎基因表达的影响，呼吸暂停综合征心室肌重构

• Kato S, Takeda Y, Miwa N (2021): Heat-retention effects of hydrogen-rich water bath assessed by thermography for humans. J Therm Biol. 2021 Jan; 95: 102805. doi: 10.1016/j.jtherbio. 2020. 102805. Epub ahead of print. 氢水沐浴对人体温的影响

• Katsumata Y, Sano F, Abe T, et al (2017): The effects of hydrogen gas inhalation on adverse left ventricular remodeling after percutaneous coronary intervention for ST-elevated myocardial infraction. First pilot study in humans. Circ J, 2017. Mar 17. doi. 10. 1253/circj. CJ-17-0105.氢气吸入对心肌梗塞介入治疗后心脏保护的临床研究

• Kayawake H, Chen-Yoshikawa TF, Saito M, et al (2020): Protective effects of a hydrogen-rich preservation solution in a canine lung transplantation model. Ann Thorac Surg 2020 Jul 7, S0003-4975 (20) 31108-5 doi 10. 1016/j. athoracsur 2020 05. 076. Online ahead of print. 氢气保存液对肺移植模型的作用，氢气减少抑制器官损伤

• Kikkawa YS, Nakagawa T, Taniguchi M, et al (2014): Hydrogen protects auditory hair cells from cisplatin-induced free radicals. Neurosci Lett, 579: 125-129.氢气对顺铂导致的听毛细胞损伤的保护，氢气对化疗药耳毒性的保护

• Kajiyama S, Hasegawa G, Asano M, et al (2008): Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance. Nutr Res, 28: 137-143. 氢水提高二型糖尿病患者脂和糖代谢，缓解糖耐量损伤

• Kajiya M, Sato K, Silva MJ, et al (2009a): Hydrogen from intestinal bacteria is protective for Concanavalin A-induced hepatitis. Biochem Biophys Res Commun 386: 316-321. 肠细菌产生氢气对肝炎的预防作用 哈佛大学的研究

• Kajiya M, Silva MJ, Sato K, et al (2009b): Hydrogen mediates suppression of colon inflammation induced by dextran sodium sulfate. Biochem Biophys Res Commun 386: 11-15. 氢气对结肠炎的治疗作用，哈佛大学的研究

• Kamimura N, Nishimaki K, Ohsawa I, et al (2011): Molecular hydrogen improves obesity and diabetes by inducing hepatic FGF21 and stimulating energy metabolism in db/db mice. Obesity (Silver Spring), 19: 1396-1403. 氢水减肥治疗糖尿病的分子机制研究。肥胖小鼠

• Kang KM, Kang YN, Choi IB, et al (2011): Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors. Med Gas Res, 1: 11.氢水对肝癌患者放疗生活质量改善的临床研究

• Kashiwagi T, Yan H, Hamasaki T, et al (2014): Electrochemically reduced water protects neural cells from oxidative damage. Oxid Med Cell Longev. 2014:869121. doi: 10.1155/2014/869121. Epub 2014 Oct 14. 电解水保护神经细胞氧化损伤

• Kasuyama K, Tomofuji T, Ekuni D, et al (2011): Hydrogen-rich water attenuates experimental periodontitis in a rat model. J Clin Periodontol. 38: 1085-1090. 氢水治疗大鼠牙周炎

• Katakura M, Hashimoto M, Tanabe Y, et al (2012): Hydrogen-rich water inhibits glucose and α,β-dicarbonyl compound-induced reactive oxygen species production in the SHR,Cg-Leprcp/NDmcr rat kidney. Med Gas Res, 2: 18. 氢水抑制葡萄糖和二羰基化合物诱导大鼠肾脏损伤

• Kato R, Nomura A, Sakamoto A, et al (2014): Hydrogen gas attenuates embryonic gene expression and prevents left ventricular remodeling induced by intermittent hypoxia in cardiomyopathic hamsters. Am J Physiol Heart Circ Physiol. 307:H1626-1633.氢气降低胚胎基因表达，预防间歇低氧诱导的仓鼠心肌重构，呼吸暂停综合征

• Kato S, Saitoh Y, Iwai K, et al (2012a): Hydrogen-rich electrolyzed warm water represses wrinkle formation against UVA ray together with type-I collagen production and oxidative-stress diminishment in fibroblasts and cell-injury prevention in keratinocytes. J Photochem Photobiol B. 106: 24-33. 电解氢水对紫外线A引起皱纹形成和上皮细胞，抑制成纤维细胞胶原产生和减少氧化应激，以及细胞损伤角质形成的预防

• Kato S, Hokama R, Okayasu H, et al (2012b): Colloidal platinum in hydrogen-rich water exhibits radical-scavenging activity and improves blood fluidity. J Nanosci Nanotechnol, 12: 4019-4027. 纳米白金在氢水清除自由基活性和提供血流速度的作用

• Kato S, Saitoh Y, Miwa N (2021): Carcinostatic effects of alkanoyl ascorbate plus platinum nano-colloid and stabilization of the esterolytically resultant ascorbate by hydrogen. Hum Cell. 34: 436-444. 烷醇基抗坏血酸与铂纳米胶体的抗癌作用，氢对酯化产物抗坏血酸盐的稳定作用

• Kawaguchi M, Satoh Y, Otsubo Y, et al (2014): Molecular hydrogen attenuates neuropathic pain in mice. PLoS ONE, 9: e100352. 氢气降低小鼠神经病理性疼

• Kawai D, Takaki A, Nakatsuka A, et al (2012): Hydrogen-rich water prevents progression of non-alcoholic steatohepatitis and accompanying hepatocarcinogenesis in mice. Hepatology. Apr 13. 氢水预防小鼠非酒精脂肪肝和肝癌的作用

• Kawamura T, Huang CS, Tochigi N, et al (2010): Inhaled hydrogen gas therapy for prevention of lung transplant-induced ischemia/reperfusion injury in rats. Transplantation, 90: 1344-1351. 氢气吸入预防肺移植诱导的缺血损伤，大鼠

• Kawamura T, Huang CS, Peng X, et al (2011): The effect of donor treatment with hydrogen on lung allograft function in rats. Surgery, 150: 240-249. 氢气对大鼠移植肺功能的影响

• Kawamura T, Wakabayashi N, Shigemura N, et al (2013): Hydrogen gas reduced hyperoxic lung injury via the Nrf2 pathway in vivo. Am J Physiol Lung Cell Mol Physiol, 304: L646-L656. 氢气诱导高氧诱导肺损伤，Nrf2通路 

• Kawamura M, Imamura R, Kobayashi Y, et al (2020): Oral administration of Si-based agent attenuates oxidative stress and ischemiareperfusion injury in a rat model: A novel hydrogen administration method. Front Med, 7: 95. 硅释放氢气对大鼠缺血再灌注损伤，新的氢气给予方法

• Kawasaki H, Guan J, tamama K (2010): Hydrogen gas treatment prolongs replicative lifespan of bone marrow multipotential stromal cells in vitro while preserving differentiation and paracrine potentials. Biochem Biophys Res Commun, 397: 608-613. 氢气延长骨髓间充质干细胞，保护气分化和旁分泌的能力

• Ke H, Liu D, Li T, et al (2020): Hydrogen-rich saline regulates microglial phagocytosis and restores behavioral deficits following hypoxia-ischemia injury in neonatal mice via the Akt pathway. Drug Des Develop Ther, 14: 3827-3839. 氢气盐水调节小胶质细胞吞噬能力，保护小鼠脑缺血缺氧导致的行为功能障碍

• Kikkawa YS, Nakagawa T, Horie RT, et al (2009): Hydrogen protects auditory hair cells from free radicals. NeuroReport, 20: 689-694. 氢气保护自由基导致的听毛细胞损伤，细胞学研究

• Kim J, Lee H, and Hong SH (2017): Inhibition of streptococcal biofilm by hydrogen water. J Dent, 2017 Mar. 58: 34-39. doi: 10. 1016/jdent. 2017. 01.004. Epub 2017 Jan 10. 氢水抑制链球菌生物膜

• Kishimoto Y, Kato T, Ito M, et al (2015): Hydrogen ameliorates pulmonary hypertension in rats by anti-inflammatory and antioxidant effects. J Thorac Cardiovasc Surg, 150: 645-654. 氢气改善肺动脉高压，大鼠，抗氧化抗炎症效应

• Kitamura A, Kobayashi S, Matsushita T, et al (2010): Experimental verification of protective effect of hydrogen-rich water against cisplatin-induced nephrotoxicity in rats using dynamic contrast-enhanced CT. Br J Radiol, 83: 509-514. 氢水对顺铂肾脏毒性，大鼠CT造影检测

• Kiyoi T, Liu S, Takemasa E, et al (2020): Constitutive hydrogen inhalation prevents vascular remodeling via reduction of oxidative stress. PLoS ONE; 15: e0227582. 氢气持续吸入预防血管内膜增生重构，1.3%氢气连续14天暴露

• Klichko VI, Safonov VI, Safonov MU, et al (2019): Supplementation with hydrogen-producing composition confers beneficial effects on physiology and life span in Drosophila. Heliyon, 5: e01679. 产氢金属镁对果蝇生理保护作用和寿命延长作用

• Kobayashi E, Sano M (2019): Organ preservation solution containing dissolved hydrogen gas from a hydrogen-absorbing alloy canister improves function of transplanted ischemic kidneys in miniature pigs. PLoS ONE, 14 (10): e0222863. 器官保护液加入氢气保护猪移植肾脏功能

• Kobayashi Y, Imamura R, Koyama Y, et al (2020): Renoprotective and neuroprotective effects of enteric hydrogen generation form Sibased agent. Sci Rep, 10: 5859. 口服硅释放氢气材料的肾脏和神经保护作用

• Kohama K, Yamashita H, Aoyama-Ishikawa M, et al (2015): Hydrogen inhalation protects against acute lung injury induced by hemorrhagic shock and resuscitation. Surgery, 158: 399-407. 氢气吸入保护急性肺损伤，出血休克+复苏

• Korovljev D, Stajer V, Javorac D, et al (2018): Hydrogen inhalation positively affects cardiometabolic risk factors in men and women aged 65 years or older: a preliminary report. Eur Geriat Med, doi 10. 1007/s41999-018-0087-6. 氢气吸入对心脏代谢危险因子的影响，65岁以上女性

• Korovljev D, Trivic T, Drid P, et al (2018): Molecular hydrogen affects body composition, metabolic profiles, and mitochondrial function in middle-aged overweight women. Ir J Med Sci, 187: 85-89. 氢气对身体组成代谢特征和线粒体功能的影响，中年超重女性

• Korovljev D, Stajer V, Ostojic J, et al (2019): Hydrogen-rich water reduces liver fat accumulation and improves liver enzyme profiles in patients with non-alcoholic fatty liver disease: a randomized controlled pilot trial. Clin Res Hepatol Gastroenterol, 2019 Apr 11. pii; S2210-7401(19)30085-3. doi: 10. 1016/j. clinre. 2019. 03. 008. 氢水对非酒精脂肪肝患者的肝脏脂肪堆积，肝脏酶学的影响，RCT

• Korovljew D, Trivic T, Stajer V, et al (2020): Short-term H2 inhalation improves cognitive function in older women: a pilot study. Int J Gerontol, 14: 149-150. 短时间氢气吸入对老年女性认知功能的改善作用，临床初步研究

• Koyama K, Tanaka Y, Saihara Y, et al (2008): Effect of hydrogen saturated alkaline electrolyzed water on urinary oxidative stress makers after an acute severe exercise: A randomized controlled trial. Anti-aging Med, 4: 117-122. (in Japanese). 氢气电解水对急性剧烈运动后尿氧化应激指标的影响，随机对照人体试验

• Koyama Y, Taura K, Hatano E, et al (2013): Effects of oral intake of hydrogen water on liver fibrogenesis in mice. Hepatol Res, 2013 May 20. doi: 10. 1111/hepr. 12165. 口服氢水对小鼠肝脏纤维化的作用

• Ku JY, Park MJ, Park HJ, et al (2020): Combination of Korean Red Ginseng extract and hydrogen-rich water improves spermatogenesis and sperm motility in male mice. Chin J Integr Med. 2020 May;26(5):361-369. doi: 10.1007/s11655-019-3047-1. Epub 2020 Jan 10. 氢水对小鼠精子活力和发生的促进作用，和朝鲜红参提取物的对比

• Kubota M, Shimura S, Kubota S, et al (2011): Hydrogen and N-acetyl-L-cysteine rescue oxidative stress-induced angiogenesis in a mouse corneal alkali-burn model. Invest Ophthalmol Vis Sci, 52: 427-433. 氢气和NAC对小鼠角膜碱性灼伤后血管增殖的作用

• Kumagai K, Toyooka T, Takeuchi S, et al (2020): Hydrogen gas inhalation improves delayed brain injury after experimental subarachnoid hemorrhage. Sci Rep, 10: 12319. 氢气吸入对蛛网膜下出血后早期脑损伤的保护作用

• Kura B, Kalocayova B, LeBaron TW, et al (2019): Regulation of microRNAs by molecular hydrogen contributes to the prevention of radiation-induced damage in the rat myocardium. Mol Cell Biochem 2019 Mar 4. doi: 10. 1007/s 1010-019-03512-z . 氢气调节微小RNA保护辐射诱导大鼠心脏损伤

• Kurioka T, Matsunobu T, Satoh Y, et al (2014): Inhaled hydrogen gas therapy for prevention of noise-induced hearing loss through reducing reactive oxygen species. Neurosci Res, 2014 Sep 6. pii: S0168-0102(14)00185-0. doi: 10. 1016/j. neures. 2014. 08. 009. 氢气吸入预防噪声诱导动物耳聋

• Kwon HJ, Han SB, Park KW (2020): Antioxidant activity of hydrogen water mask pack composed of gel-type emulsion and hydrogen generation powder. Int J Mol Sci, 21(24): 9731. 氢水面膜抗氧化效应研究