Jawad, M., Uthirapathy, S., Altalbawy, F.M.A. et al. Examining the role of antioxidant supplementation in mitigating oxidative stress markers in Alzheimer’s disease: a comprehensive review. Inflammopharmacol (2024). https://doi.org/10.1007/s10787-024-01622-9

该文中有一小段谈论氢气用于该疾病的研究：

Molecular hydrogen

Another antioxidant that can lower inflammation and modify the Keap1-Nrf2-ARE signalling pathway is molecular hydrogen (Slezák et al.2016). It may play a part in the specific decrease of hydroxyl radicals that break down proteins and nucleic acid and cause lipid peroxidation, which has also been linked to AD (Ohsawa et al. 2007). Molecular hydrogen treatment has been shown to extend life and boost the survival of short-lived Drosophila (Klichko, et al. 2019). Simultaneously, the increase in glutathione and SOD levels is discovered to be caused by the hydrogen-rich water (Veurink et al. 2020). With a dual function of indirect and direct, molecular hydrogen treatment yields positive outcomes for AD. For solid recommendations and suggestions, further human trials are necessary.

分子氢 另一种能够减轻炎症并调节Keap1-Nrf2-ARE信号通路的抗氧化剂是分子氢（斯莱扎克等人，2016年）。它可能在特异性减少羟基自由基方面发挥作用，羟基自由基会分解蛋白质和核酸并引发脂质过氧化，而脂质过氧化也与阿尔茨海默病（AD）有关（大泽等人，2007年）。已有研究表明，分子氢疗法能够延长寿命并提高短寿命果蝇的存活率（克利奇科等人，2019年）。同时，人们发现富氢水会使谷胱甘肽和超氧化物歧化酶（SOD）水平升高（维林克等人，2020年）。分子氢疗法凭借间接和直接的双重作用，对阿尔茨海默病产生了积极的治疗效果。不过，要想获得可靠的推荐意见和建议，还需要开展进一步的人体试验。